The remarkable efficacy of Wellbeing International Foundation’s treatments is grounded in extensive scientific research focusing on muscle tissue regeneration. Dr. Stephen Ray, the foundation’s Chief Scientist, has conducted groundbreaking studies that illuminate the mechanisms behind their cell-free therapy and its impact on muscle recovery.
At the heart of this research is the understanding that muscles are maintained by specialised cells called satellite cells. These cells, which normally reside in a resting state between the basement membrane and sarcolemma of muscle fibres, become activated during exercise or injury, proliferating to form new muscle tissue. However, with disuse or ageing, these satellite cells become more difficult to activate, leading to reduced muscle maintenance and repair capability.
Wellbeing’s approach focuses on stimulating these satellite cells through extracellular vesicles (EVs) derived from mesenchymal stem cells. Research published by Dr. Ray and colleagues demonstrates that these EVs contain crucial growth factors including insulin-like growth factor 1 (IGF-1), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF)—all essential for muscle regeneration.
One particularly notable finding comes from a collaboration with Professor Patel’s laboratory at the University of Reading. Their research showed that EVs from mesenchymal stem cells significantly increase the proliferation of muscle progenitor cells and stimulate their differentiation into mature muscle tissue. Most remarkably, while untreated satellite cells typically take 21 days to produce functional myotubes, cells treated with EVs achieved the same result in just 5 days.
The foundation’s research also highlights the importance of heat shock proteins (HSP 60, HSP 90, and HSP 105) contained in stem cell secretions. These proteins, produced by cells under stress, activate numerous pro-regenerative processes essential for effective recovery.
By publishing their findings and collaborating with respected academic institutions, Wellbeing International Foundation continues to advance the field of regenerative medicine. Their research not only validates their therapeutic approach but also contributes valuable knowledge to the broader scientific community, furthering our understanding of muscle recovery and regeneration.